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Research   Open Access

An optimized workflow for improved gene expression profiling for formalin-fixed, paraffin-embedded tumor samples

Marlene Thomas, Manuela Poignée-Heger, Martin Weisser, Stephanie Wessner, Anton Belousov Journal of Clinical Bioinformatics 2013, 3:10 (3 May 2013)

Abstract | Provisional PDF | PubMed

Methodology   Open Access

A diagnostic methodology for Alzheimer's disease

Wen-Chin Hsu, Christopher Denq, Su-Shing Chen Journal of Clinical Bioinformatics 2013, 3:9 (25 April 2013)

Abstract | Provisional PDF | PubMed

Research   Open Access

Characteristics of cross-hybridization and cross-alignment of expression in pseudo-xenograft samples by RNA-Seq and microarrays

Camilo Valdes, Pearl Seo, Nicholas Tsinoremas, Jennifer Clarke Journal of Clinical Bioinformatics 2013, 3:8 (18 April 2013)

Abstract | Provisional PDF | PubMed

Database   Open Access

TUMIR: an experimentally supported database of microRNA deregulation in various cancers

Lei Dong, Min Luo, Fang Wang, Junwu Zhang, Tingting Li, Jia Yu Journal of Clinical Bioinformatics 2013, 3:7 (17 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

Reviewer acknowledgement   Open Access

Annual acknowledgement of manuscript reviewers

Xiangdong Wang Journal of Clinical Bioinformatics 2013, 3:5 (22 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

Review   Open Access Highly Accessed

MicroRNAs: an emerging science in cancer epigenetics

Rishabh Kala, Gregory W Peek, Tabitha M Hardy, Trygve O Tollefsbol Journal of Clinical Bioinformatics 2013, 3:6 (16 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

Methodology   Open Access

Improved branch and bound algorithm for detecting SNP-SNP interactions in breast cancer

Li-Yeh Chuang, Hsueh-Wei Chang, Ming-Cheng Lin, Cheng-Hong Yang Journal of Clinical Bioinformatics 2013, 3:4 (14 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

Research   Open Access

Cystic fibrosis testing in a referral laboratory: results and lessons from a six-year period

Perry G Ridge, Christine Miller, Pinar Bayrak-Toydemir, D Hunter Best, Rong Mao, Jeffrey J Swensen, Elaine Lyon, Karl V Voelkerding Journal of Clinical Bioinformatics 2013, 3:3 (23 January 2013)

Abstract | Full text | PDF | PubMed

Research   Open Access

A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome

Walter Arancio, Carla Giordano, Giuseppe Pizzolanti Journal of Clinical Bioinformatics 2013, 3:2 (14 January 2013)

Abstract | Full text | PDF | PubMed

Research   Open Access

Availability of MudPIT data for classification of biological samples

Dario Silvestre, Italo Zoppis, Francesca Brambilla, Valeria Bellettato, Giancarlo Mauri, Pierluigi Mauri Journal of Clinical Bioinformatics 2013, 3:1 (14 January 2013)

Abstract | Full text | PDF | PubMed

Database   Open Access Highly Accessed

PROGmiR: a tool for identifying prognostic miRNA biomarkers in multiple cancers using publicly available data

Chirayu Pankaj Goswami, Harikrishna Nakshatri Journal of Clinical Bioinformatics 2012, 2:23 (28 December 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

mCOPA: analysis of heterogeneous features in cancer expression data

Chenwei Wang, Alperen Taciroglu, Stefan R Maetschke, Colleen C Nelson, Mark A Ragan, Melissa J Davis Journal of Clinical Bioinformatics 2012, 2:22 (10 December 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access Highly Accessed

Genome-wide Profiling of RNA splicing in prostate tumor from RNA-seq data using virtual microarrays

Subhashini Srinivasan, Arun H Patil, Mohit Verma, Jonathan L Bingham, Raghunathan Srivatsan Journal of Clinical Bioinformatics 2012, 2:21 (26 November 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Using gene expression data to identify certain gastro-intestinal diseases

Philip S Crooke, John T Tossberg, Sara N Horst, John L Tauscher, Melodie A Henderson, Dawn B Beaulieu, David A Schwartz, Nancy J Olsen, Thomas M Aune Journal of Clinical Bioinformatics 2012, 2:20 (21 November 2012)

Abstract | Full text | PDF | PubMed

Database   Open Access Highly Accessed

Huvariome: a web server resource of whole genome next-generation sequencing allelic frequencies to aid in pathological candidate gene selection

Andrew Stubbs, Elizabeth A McClellan, Sebastiaan Horsman, Saskia D Hiltemann, Ivo Palli, Stephan Nouwens, Anton HJ Koning, Frits Hoogland, Joke Reumers, Daphne Heijsman, Sigrid Swagemakers, Andreas Kremer, Jules Meijerink, Diether Lambrechts, Peter J van der Spek Journal of Clinical Bioinformatics 2012, 2:19 (19 November 2012)

Abstract | Full text | PDF | PubMed

Short report   Open Access

The H-factor as a novel quality metric for homology modeling

Eric di Luccio, Patrice Koehl Journal of Clinical Bioinformatics 2012, 2:18 (2 November 2012)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Modeling autism: a systems biology approach

Mary Randolph-Gips, Pramila Srinivasan Journal of Clinical Bioinformatics 2012, 2:17 (8 October 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Cancer classification: Mutual information, target network and strategies of therapy

Wen-Chin Hsu, Chan-Cheng Liu, Fu Chang, Su-Shing Chen Journal of Clinical Bioinformatics 2012, 2:16 (2 October 2012)

Abstract | Full text | PDF | PubMed

Short report   Open Access

High-prevalence and broad spectrum of Cell Adhesion and Extracellular Matrix gene pathway mutations in epithelial ovarian cancer

Arash Rafii, Najeeb M Halabi, Joel A Malek Journal of Clinical Bioinformatics 2012, 2:15 (24 September 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

A model-based statistic for detecting molecular markers associated with complex survival patterns in early-stage cancer

Philippe Broët, Thierry Moreau Journal of Clinical Bioinformatics 2012, 2:14 (6 August 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes

Xiaowei Guan, Mark R Chance, Jill S Barnholtz-Sloan Journal of Clinical Bioinformatics 2012, 2:13 (22 May 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Effects of autoclaving and high pressure on allergenicity of hazelnut proteins

Elena López, Carmen Cuadrado, Carmen Burbano, Maria Jiménez, Julia Rodríguez, Jesús F Crespo Journal of Clinical Bioinformatics 2012, 2:12 (22 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology   Open Access Highly Accessed

A dynamic model for tumour growth and metastasis formation

Volker Haustein, Udo Schumacher Journal of Clinical Bioinformatics 2012, 2:11 (1 May 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse

Yuqi Zhao, Jingwen Wang, Yanjie Wang, Jingfei Huang Journal of Clinical Bioinformatics 2012, 2:10 (1 May 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

An eUtils toolset and its use for creating a pipeline to link genomics and proteomics analyses to domain-specific biomedical literature

Prakash M Nadkarni, Chirag R Parikh Journal of Clinical Bioinformatics 2012, 2:9 (16 April 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome

Khader Shameer, Ramanathan Sowdhamini Journal of Clinical Bioinformatics 2012, 2:8 (3 April 2012)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Bioinformatics as a driver, not a passenger, of translational biomedical research: Perspectives from the 6th Benelux bioinformatics conference

Francisco J Azuaje, Michaël Heymann, Anne-Marie Ternes, Anke Wienecke-Baldacchino, Daniel Struck, Danièle Moes, Reinhard Schneider Journal of Clinical Bioinformatics 2012, 2:7 (13 March 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease

Rizwan Masud, Khader Shameer, Aparna Dhar, Keyue Ding, Iftikhar J Kullo Journal of Clinical Bioinformatics 2012, 2:6 (12 March 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

Monte Carlo simulation of the Spearman-Kaerber TCID50

Niels H Wulff, Maria Tzatzaris, Philip J Young Journal of Clinical Bioinformatics 2012, 2:5 (13 February 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Analysis of the salivary microbiome using culture-independent techniques

Vladimir Lazarevic, Katrine Whiteson, Nadia Gaïa, Yann Gizard, David Hernandez, Laurent Farinelli, Magne Østerås, Patrice François, Jacques Schrenzel Journal of Clinical Bioinformatics 2012, 2:4 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

A distinct metabolic signature predicts development of fasting plasma glucose

Manuela Hische, Abdelhalim Larhlimi, Franziska Schwarz, Antje Fischer-Rosinský, Thomas Bobbert, Anke Assmann, Gareth S Catchpole, Andreas FH Pfeiffer, Lothar Willmitzer, Joachim Selbig, Joachim Spranger Journal of Clinical Bioinformatics 2012, 2:3 (2 February 2012)

Abstract | Full text | PDF | PubMed

Short report   Open Access

Brain cancer prognosis: independent validation of a clinical bioinformatics approach

Raffaele Fronza, Michele Tramonti, William R Atchley, Christine Nardini Journal of Clinical Bioinformatics 2012, 2:2 (1 February 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer

Shih-Heng Yeh, Hsiang-Yuan Yeh, Von-Wun Soo Journal of Clinical Bioinformatics 2012, 2:1 (13 January 2012)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Characterization of uncertainty in the classification of multivariate assays: application to PAM50 centroid-based genomic predictors for breast cancer treatment plans

Mark TW Ebbert, Roy RL Bastien, Kenneth M Boucher, Miguel Martín, Eva Carrasco, Rosalía Caballero, Inge J Stijleman, Philip S Bernard, Julio C Facelli Journal of Clinical Bioinformatics 2011, 1:37 (23 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach

Emmanouil G Sifakis, George I Lambrou, Andriana Prentza, Spiros Vlahopoulos, Dimitris Koutsouris, Fotini Tzortzatou-Stathopoulou, Aristotelis A Chatziioannou Journal of Clinical Bioinformatics 2011, 1:36 (20 December 2011)

Abstract | Full text | PDF | PubMed

Review   Open Access

Significance of bioinformatics in research of chronic obstructive pulmonary disease

Hong Chen, Xiangdong Wang Journal of Clinical Bioinformatics 2011, 1:35 (20 December 2011)

Abstract | Full text | PDF | PubMed

Short report   Open Access

Profiling the human response to physical exercise: a computational strategy for the identification and kinetic analysis of metabolic biomarkers

Michael Netzer, Klaus M Weinberger, Michael Handler, Michael Seger, Xiaocong Fang, Karl G Kugler, Armin Graber, Christian Baumgartner Journal of Clinical Bioinformatics 2011, 1:34 (19 December 2011)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Mathematical morphology-based approach to the enhancement of morphological features in medical images

Yoshitaka Kimori Journal of Clinical Bioinformatics 2011, 1:33 (16 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

Clinical data integration of distributed data sources using Health Level Seven (HL7) v3-RIM mapping

Teeradache Viangteeravat, Matthew N Anyanwu, Venkateswara Nagisetty, Emin Kuscu, Mark Sakauye, Duojiao Wu Journal of Clinical Bioinformatics 2011, 1:32 (21 November 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Proteome analysis of bronchoalveolar lavage in pulmonary langerhans cell histiocytosis

Claudia Landi, Elena Bargagli, Barbara Magi, Antje Prasse, Joachim Muller-Quernheim, Luca Bini, Paola Rottoli Journal of Clinical Bioinformatics 2011, 1:31 (10 November 2011)

Abstract | Full text | PDF | PubMed

Review   Open Access

Metabonomics-based omics study and atherosclerosis

Duo-jiao Wu, Bi-jun Zhu, Xiang-dong Wang Journal of Clinical Bioinformatics 2011, 1:30 (31 October 2011)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Diagnostic markers based on a computational model of lipoprotein metabolism

Daniël B van Schalkwijk, Ben van Ommen, Andreas P Freidig, Jan van der Greef, Albert A de Graaf Journal of Clinical Bioinformatics 2011, 1:29 (26 October 2011)

Abstract | Full text | PDF | PubMed

Editorial   Open Access

Role of clinical bioinformatics in the development of network-based Biomarkers

Xiangdong Wang Journal of Clinical Bioinformatics 2011, 1:28 (24 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology   Open Access

Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection

Konstantina Dimitrakopoulou, Charalampos Tsimpouris, George Papadopoulos, Claudia Pommerenke, Esther Wilk, Kyriakos N Sgarbas, Klaus Schughart, Anastasios Bezerianos Journal of Clinical Bioinformatics 2011, 1:27 (21 October 2011)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Technical phosphoproteomic and bioinformatic tools useful in cancer research

Elena López, Jan-Jaap Wesselink, Isabel López, Jesús Mendieta, Paulino Gómez-Puertas, Sarbelio Muñoz Journal of Clinical Bioinformatics 2011, 1:26 (3 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access Highly Accessed

Automated ERCC1 immunochemistry on hybrid cytology/tissue microarray of malignant effusions: evaluation of antibodies 8F1 and D-10

Alex Soltermann, Sandra Kilgus-Hawelski, Silvia Behnke, Martina Storz, Holger Moch, Beata Bode Journal of Clinical Bioinformatics 2011, 1:25 (30 September 2011)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Biobank resources for future patient care: developments, principles and concepts

Ákos Végvári, Charlotte Welinder, Henrik Lindberg, Thomas E Fehniger, György Marko-Varga Journal of Clinical Bioinformatics 2011, 1:24 (16 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access Highly Accessed

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study

Masaharu Nomura, Tetsuya Fukuda, Kiyonaga Fujii, Takeshi Kawamura, Hiromasa Tojo, Makoto Kihara, Yasuhiko Bando, Adi F Gazdar, Masahiro Tsuboi, Hisashi Oshiro, Toshitaka Nagao, Tatsuo Ohira, Norihiko Ikeda, Noriko Gotoh, Harubumi Kato, Gyorgy Marko-Varga, Toshihide Nishimura Journal of Clinical Bioinformatics 2011, 1:23 (3 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Database   Open Access

Leveraging a clinical research information system to assist biospecimen data and workflow management: a hybrid approach

Prakash M Nadkarni, Rowena Kemp, Chirag R Parikh Journal of Clinical Bioinformatics 2011, 1:22 (25 August 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma

Gurkan Bebek, Mohammed Orloff, Charis Eng Journal of Clinical Bioinformatics 2011, 1:21 (2 August 2011)

Abstract | Full text | PDF | PubMed

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